Relationship between Vitamin C, Mast Cells and Inflammation
نویسندگان
چکیده
Vitamin C deficiency causes scurvy and can compromise many bodily functions. Vitamin C is involved in mast cells and other immune cells, such as NK cells, and differentiation of Th0 subset into Th1 cells. In addition, vitamin C has an important effect on p38 MAPK pathway and NF-kappa activity. Vitamin C is an anti-oxidant which protects the immune cells against intracellular ROS generated in allergic inflammatory response. Administration of vitamin C opposes free radical production and decreases bronchial hypersensitivity, an effect mediated by mast cells. Here, in this paper, we studied the relationship between vitamin C, mast cells and inflammation.
منابع مشابه
Mast cells and histopathologic variants of basal cell carcinoma
Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...
متن کاملبررسی حضور ماستسلها درپریودنتیت مهاجم
Background and Objective: Aggressive periodontitis is a destructive disease that leads to a quick and extensive periodontal tissue loss. Mast cells are known to play important roles in allergic reactions, host defense against bacterial infections, local homeostasis, inflammation, and angiogenesis. The aim of the present study was to evaluate the relationship between mast cell numbers and aggres...
متن کاملشمارش ماست سل ها در بافت پریودنتال بیمار و سالم
Background and purpose: Periodontitis and gingivitis are inflammatory diseases in supporting tissues of tooth. Mast cells are inflammatory cells that can participate in destruction of connective tissue in periodontal diseases. In this study we evaluated mast cells count in gingival tissues in individuals with periodontal diseases and compared that with those in healthy people. Materials and ...
متن کاملP164: The Role of Mast Cells in the Pathogenesis of Anxiety Disorders
Mast cells are a heterogeneous population of granulocytic cells in the immune system. Mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. In addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...
متن کامل